Article
Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2004
Qian Ye, Wang Hongsheng, Clarke Stephen H
Abstract excerpt
Since apoptotic cell Ags are thought to be a source of self-Ag in systemic lupus erythematosus, we have examined the role of apoptotic cells in the regulation and activation of B cells specific for Sm, a ribonucleoprotein targeted in human and murine lupus. Using Ig-transgenic mice that have a high frequency of anti-Sm B cells, we find that apoptotic cell injection induces a transient splenic B cell response,...
Topics
- Animals
- Apoptosis
- Autoantigens
- B-Lymphocyte Subsets
- Cell Death
- Epitopes, B-Lymphocyte
- Lymphocyte Activation
- Lymphopenia
- Mice
- Mice, Transgenic
- Mutation