Article
Aged mice exhibit in vivo defective peripheral clonal deletion of D(b)/H-Y reactive CD8(+) T cells.
Mechanisms of ageing and development - 1 Mar 2001
Hsu H C, Zhou T, Shi J, Yang P A, Liu D, Zhang H G, Bluethmann H, Mountz J D
Abstract excerpt
We previously reported that T cells from aged mice were resistant to activation-induced cell death (AICD) in vitro. To determine whether the presence of AICD-resistant T cells is associated with defects in age-related peripheral clonal deletion in vivo, congenic male SCID mice were reconstituted with T cells from aged or young female D(b)/H-Y TCR (Tg71) transgenic mice. Compared with recipients of young cells,...
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