Article
Apoptosis accompanies a change in the phenotypic distribution and functional capacity of murine bone marrow B-cells chronically exposed to prednisolone.
Clinical immunology and immunopathology - 1 May 1994
Voetberg B J, Garvy B A, Mayer H K, King L E, Fraker P J
Abstract excerpt
Prednisolone (PD) is commonly used for the treatment of inflammation accompanying diseases such as arthritis, allergy, asthma, and autoimmunity. While it is well documented that PD induces apoptosis in immature T-cells of the mouse, the effects of PD on development of immature B-cells in normal bone marrow (BM) was not known. An implantation system was developed which chronically delivered PD at a rate of a few...
Topics
- Animals
- Antigens
- Apoptosis
- B-Lymphocytes
- Bone Marrow
- Bone Marrow Cells
- Growth
- Immunosuppressive Agents
- Lipopolysaccharides
- Male
- Mice