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Article

Radiation-induced apoptosis is differentially regulated in primary B cells from normal mice and mice with the CBA/N X-linked immunodeficiency.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1995

Woodland R T, Schmidt M R, Riggs J E, Korsmeyer S J, Lussier A M, Gravel K A

Abstract excerpt

Normal B cells responsive to thymus independent-type 1 Ags (TI-1) are resistant to low doses of ionizing radiation in vivo (200-300 cGy), compared with TI-1 responsive B cells of mice with the CBA/N X-linked immunodeficiency (xid). This difference in radiosensitivity is an intrinsic B cell property; normal B cells adoptively transferred into xid mice remain TI-1-responsive after irradiation in situ. Because...

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PMID: 7561040

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