Variants selected by treatment of human immunodeficiency virus-infected cells with an immunotoxin.

doi:10.1084/jem.172.3.745

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Article

Variants selected by treatment of human immunodeficiency virus-infected cells with an immunotoxin.

The Journal of experimental medicine - 1 Sept 1990

Pincus S H, Wehrly K, Tschachler E, Hayes S F, Buller R S, Reitz M

Abstract excerpt

An immunotoxin has been made by coupling anti-human immunodeficiency virus (HIV) envelope antibody 907 to ricin A chain (907-RAC). 907 recognizes an epitope within the immunodominant PB-1 loop of gp120. Variant cells were selected by cloning persistently infected H9/human T lymphocyte virus IIIB cells in the presence of the immunotoxin. Clones resistant to 907-RAC arose at a frequency of 0.1-1.0%. Seven clones...

Topics

Base Sequence
CD4 Antigens
Cell Line
Cell Transformation, Viral
Clone Cells
DNA, Viral
Epitopes
Genes, Viral
Genetic Variation
HIV
HIV Envelope Protein gp120

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HeLa Cells

Humans

Immunotoxins

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 1696955
DOI: 10.1084/jem.172.3.745
PMCID: PMC2188557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1696955-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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