Article
Spontaneous reversion of human immunodeficiency virus type 1 neutralization-resistant variant HXB2thr582: in vitro selection against cytopathicity highlights gp120-gp41 interactive regions.
Journal of virology - 1 Mar 1995
Stern T L, Reitz M S, Robert-Guroff M
Abstract excerpt
Spontaneous revertants of the immune-selected variant HXB2thr582, which resists neutralization by certain conformationally dependent antibodies specific for the CD4-binding site on gp120 (such as F105), appeared after long-term culture in the absence of immune-selecting serum. Molecular analysis...
Topics
- Amino Acid Sequence
- Base Sequence
- Cells, Cultured
- Clone Cells
- Cytopathogenic Effect, Viral
- DNA, Viral
- HIV Antibodies
- HIV Antigens
- HIV Envelope Protein gp120
- HIV Envelope Protein gp41
- HIV-1
- Humans
- In Vitro Techniques
- Molecular Sequence Data
- Mutation
- Neutralization Tests
- Protein Binding