Article
In vitro selective elimination of HIV-infected cells from peripheral blood in AIDS patients by the immunotoxin DAB389CD4.
AIDS (London, England) - 28 May 1998
Martín-Serrano J, Folgueira L, Laín de Lera T, Pedraza M A, Lemichez E, Sánchez-Palomino S, Noriega A R, Boquet P, Alcamí J
Abstract excerpt
OBJECTIVES: To study the antiviral efficacy of the recombinant immunotoxin DAB389CD4 against wild-type strains of HIV and to analyse its potential toxicity in non-infected peripheral blood mononuclear cells (PBMC). DESIGN AND METHODS: PBMC from HIV-seropositive patients were cultured in the prese...
Topics
- Anti-HIV Agents
- CD4 Antigens
- Cell Survival
- Cells, Cultured
- Diphtheria Toxin
- Dose-Response Relationship, Drug
- HIV
- HIV Core Protein p24
- Humans
- Immunotoxins
- Leukocytes, Mononuclear
- Phenotype
- Proviruses
- RNA, Viral
- Recombinant Fusion Proteins
- Virus Replication