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Article

The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication.

Journal of virology - 1 Feb 1996

de Vreese K, Kofler-Mongold V, Leutgeb C, Weber V, Vermeire K, Schacht S, Anné J, de Clercq E, Datema R, Werner G

Abstract excerpt

Bicyclams are a novel class of antiviral compounds which act as potent and selective inhibitors of the replication of human immunodeficiency virus type 1 (HIV-1) and HIV-2. They block an early step in the viral life cycle following adsorption to the CD4 receptor and preceding reverse transcription. To identify the molecular target of these compounds, we genetically analyzed variants of the HIV-1 molecular clone...

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Identifiers

PMID: 8551604
DOI: 10.1128/JVI.70.2.689-696.1996
PMCID: PMC189868

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