Article
The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication.
Journal of virology - 1 Feb 1996
de Vreese K, Kofler-Mongold V, Leutgeb C, Weber V, Vermeire K, Schacht S, Anné J, de Clercq E, Datema R, Werner G
Abstract excerpt
Bicyclams are a novel class of antiviral compounds which act as potent and selective inhibitors of the replication of human immunodeficiency virus type 1 (HIV-1) and HIV-2. They block an early step in the viral life cycle following adsorption to the CD4 receptor and preceding reverse transcriptio...
Topics
- Amino Acid Sequence
- Antiviral Agents
- Base Sequence
- Benzylamines
- Binding Sites
- Cell Line
- Cyclams
- Drug Resistance, Microbial
- Genes, env
- HIV Envelope Protein gp120
- HIV-1
- Heterocyclic Compounds
- Humans
- Molecular Sequence Data
- Mutation