Article

Anti-HIV Immunotoxin and Antibody-Drug Conjugate Display Both Common and Distinct Effects in Killing Target Cells

2026-04-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In the course of testing mAb-based therapies to eradicate the persistent reservoir of HIV infection, we investigated the efficacy and mode of killing of HIV-infected cells by two categories of cytotoxic immunoconjugates (CICs) targeted by the same mAb, an immunotoxin (IT) and antibody-drug conjugate (ADC). <h4>Methods</h4> We performed metabolic and transcriptional analyses...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67b4d470-7c29-5695-bea1-fca3e11371b2
DOI: 10.64898/2026.04.07.717054

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anti-HIV Immunotoxin and Antibody-Drug Conjugate Display Both Common and Distinct Effects in Killing Target CellsDOI 10.64898/2026.04.07.717054Read

Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4 <sup>+</sup> T-cellsSemantic proximity Read

Targeted Intracellular Delivery of Trastuzumab Using Designer Phage Lambda Nanoparticles Alters Cellular Programs in Human Breast Cancer CellsSemantic proximity Read

Patritumab deruxtecan induces immunogenic cell deathSemantic proximity Read

Target product profile for cell-based and gene-based therapies to achieve a cure for HIVSemantic proximity Read

Nuclear-based labeling of cellular immunotherapies: a simple protocol for preclinical useSemantic proximity Read

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistanceSemantic proximity Read

Identification of antibody-drug conjugate payloads which are substrates of ATP-binding cassette drug efflux transportersSemantic proximity Read

Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer.Semantic proximity Read

Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection modelSemantic proximity Read

Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic EfficacySemantic proximity Read

Self-Assembling Antisense Oligo-RNA Structures and M2-M1 Macrophage Phenotype Transformers for Cancer TreatmentSemantic proximity Read

High-throughput kinetic analysis for target-directed covalent ligand discoverySemantic proximity Read