Abnormal X chromosome inactivation and tumor development.

Abstract excerpt

During embryonic development, one of the two X chromosomes of a mammalian female cell is randomly inactivated by the X chromosome inactivation mechanism, which is mainly dependent on the regulation of the non-coding RNA X-inactive specific transcript at the X chromosome inactivation center. There are three proteins that are essential for X-inactive specific transcript to function properly: scaffold attachment...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to RNA, Long Noncoding
• Share to Chromosomes, Human, X