Article
Non-random X chromosome inactivation in Aicardi syndrome.
Human genetics - 1 Mar 2009
Eble Tanya N, Sutton V Reid, Sangi-Haghpeykar Haleh, Wang Xiaoling, Jin Weihong, Lewis Richard A, Fang Ping, Van den Veyver Ignatia B
Abstract excerpt
Most females have random X-chromosome inactivation (XCI), defined as an equal likelihood for inactivation of the maternally- or paternally-derived X chromosome in each cell. Several X-linked disorders have been associated with a higher prevalence of non-random XCI patterns, but previous studies on XCI patterns in Aicardi syndrome were limited by small numbers and older methodologies, and have yielded conflicting...
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