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Article

Extremely skewed X-chromosome inactivation is increased in pre-eclampsia.

Human genetics - 1 Mar 2007

Uz Elif, Dolen Ismail, Al Atakan R, Ozcelik Tayfun

Abstract excerpt

Pre-eclampsia is a disorder that affects approximately 5% of pregnancies. We tested the hypothesis that skewed X-chromosome inactivation (XCI) could be involved in the pathogenesis of pre-eclampsia. Peripheral blood DNA was obtained from 67 pre-eclampsia patients and 130 control women. Androgen receptor (AR) was analyzed by the HpaII/polymerase chain reaction assay to assess XCI patterns in DNA extracted from...

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PMID: 17115188
DOI: 10.1007/s00439-006-0281-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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