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Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease.

Cell reports - 30 Jun 2020

Park Goonho, Nhan Hoang S, Tyan Sheue-Houy, Kawakatsu Yusuke, Zhang Carolyn, Navarro Mario, Koo Edward H

Abstract excerpt

Amyloid β-protein (Aβ) toxicity is hypothesized to play a seminal role in Alzheimer's disease (AD) pathogenesis. However, it remains unclear how Aβ causes synaptic dysfunction and synapse loss. We hypothesize that one mechanism of Aβ-induced synaptic injury is related to the cleavage of amyloid β precursor protein (APP) at position D664 by caspases that release the putatively cytotoxic C31 peptide. In organotypic...

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Identifiers

PMID: 32610140
DOI: 10.1016/j.celrep.2020.107839
PMCID: PMC7375398

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