Article
Effect of phorbol myristate acetate on T cell colony formation, interleukin-2 (IL-2) receptor expression and IL-2 production by cells from patients at all stages of HIV infection.
Clinical and experimental immunology - 1 Aug 1990
Allouche M, Lunardi-Iskandar Y, Varela-Millot C, Itzhaki M, Cornuet P, Meyer P, Jasmin C, Georgoulias V
Abstract excerpt
We and others have shown that several T cell responses induced by the mitogen phytohaemagglutinin (PHA), including T cell colony formation, IL-2 receptor (IL-2R) expression, and IL-2 production are impaired in patients with AIDS and lymphadenopathy syndrome (LAS). We investigated whether phorbol myristate acetate (PMA) could act in synergy with PHA (as it does in healthy subjects) to enhance in vitro T cell...
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