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Article

Prostratin: activation of latent HIV-1 expression suggests a potential inductive adjuvant therapy for HAART

15 Nov 2001

Abstract excerpt

Prostratin is a unique phorbol ester that stimulates protein kinase C activity but is nontumor promoting. Remarkably, prostratin is also able to inhibit de novo human immunodeficiency virus type 1 (HIV-1) infection yet up-regulate viral expression from latent proviruses. Prostratin's lack of tumor promotion, coupled with its ability to block viral spread yet induce latent proviral expression, prompted studies to...

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Identifiers

PMID: 11698284
DOI: 10.1182/blood.v98.10.3006

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