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Article

Effect of HIV infection on the frequency of cytokine-secreting cells in human peripheral blood.

AIDS research and human retroviruses - 20 Jan 1996

Hagiwara E, Sacks T, Leitman-Klinman S F, Klinman D M

Abstract excerpt

A selective decrease in type 1 cytokine secretion by in vitro stimulated peripheral blood cells is reportedly associated with disease progression in HIV-infected individuals. To examine whether a similar change in cytokine secretion occurs under physiologic conditions in vivo, sensitive and specific ELIspot assays were used to compare the phenotype and frequency of PBMC spontaneously producing interleukin (IL)-2,...

Topics

Cytokines
HIV
HIV Infections
Humans
Interferon-gamma
Interleukin-10
Interleukin-2
Interleukin-4
Leukocytes, Mononuclear
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8834462
DOI: 10.1089/aid.1996.12.127

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