Article
Induction of NF-kappa B during monocyte differentiation is associated with activation of HIV-gene expression.
Research in virology - 1 Jan 2000
Griffin G E, Leung K, Folks T M, Kunkel S, Nabel G J
Abstract excerpt
Cells of the monocyte-macrophage lineage are important targets of HIV infection. We report here that the phenotypic differentiation of monocyte cell lines induced by phorbol esters or tumour necrosis factor alpha (TNF alpha) is associated with expression of nuclear factor kappa B (NF-kappa B). In parallel with such differentiation, HIV transcription, monitored using an HIV long terminal repeat reporter gene...
Topics
- Cell Differentiation
- Cell Line
- Chloramphenicol O-Acetyltransferase
- Gene Expression Regulation, Viral
- HIV-1
- Humans
- Monocytes
- NF-kappa B
- Phenotype
- Tetradecanoylphorbol Acetate
- Transcription, Genetic