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Article

Effects of Prostratin on T-Cell Activation and Human Immunodeficiency Virus Latency

28 Jul 2002

Abstract excerpt

Human immunodeficiency virus (HIV) replication is linked to cellular gene transcription and requires target cell activation. The latent reservoir of HIV-1 in quiescent T cells is thought to be a major obstacle to clearance of infection by highly active antiretroviral therapy (HAART). Thus, identification of agents that can induce expression of latent virus may, in the presence of HAART, allow elimination of the...

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Identifiers

PMID: 12134017
DOI: 10.1128/jvi.76.16.8118-8123.2002

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