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Article

QTL-specific genotype-by-smoking interaction and burden of calcified coronary atherosclerosis: the NHLBI Family Heart Study.

Atherosclerosis - 1 Jul 2007

North K E, Carr J J, Borecki I B, Kraja A, Province M, Pankow J S, Wilk J B, Hixson J E, Heiss G

Abstract excerpt

BACKGROUND: Calcified coronary plaque (CCP) is a complex trait influenced by both genes and environment, and plausibly an interaction between the two. Because the familial aggregation of CCP has been demonstrated and smoking is a significant, independent predictor of CCP, we assessed the evidence for genotype-by-smoking interaction and conducted linkage analysis of quantitative Agatston CCP scores in participants...

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Identifiers

PMID: 16965775
DOI: 10.1016/j.atherosclerosis.2006.08.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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