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Article

A comprehensive multi-layered analysis reveals genetic pleiotropy underlying coronary artery calcification and bone mineral density.

Bone - 1 Feb 2026

Han Tao, Qu Yang, Zhu Jiangbo, Sha Linna, Lei Bowen, Xiang Rong, Zhao Xunying, Hou Jiaojiao, Deng Qin, Zheng Sirui, Zhou Jinyu, Yu Ting, Song Xin, Yang Bin, Zhong Yangdan, Xia Maoyao, Kiel Douglas P, Jiang Xia

Abstract excerpt

OBJECTIVES: Subclinical atherosclerosis and osteoporosis are often present together in the same individual, but their common mechanisms remain unclear. This study aims to investigate the pleiotropic relationship underlying coronary artery calcification (CAC) and estimated calcaneal bone mineral density (eBMD), providing molecular insights into their observed phenotypic associations. METHODS: Genetic correlation...

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Identifiers

PMID: 41205692
DOI: 10.1016/j.bone.2025.117719
PMCID: PMC12928696

Genes

SMG6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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