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Article

Genome-wide association study of gene by smoking interactions in coronary artery calcification.

PloS one - 1 Jan 2013

Polfus Linda M, Smith Jennifer A, Shimmin Lawrence C, Bielak Lawrence F, Morrison Alanna C, Kardia Sharon L R, Peyser Patricia A, Hixson James E

Abstract excerpt

Many GWAS have identified novel loci associated with common diseases, but have focused only on main effects of individual genetic variants rather than interactions with environmental factors (GxE). Identification of GxE interactions is particularly important for coronary heart disease (CHD), a major preventable source of morbidity and mortality with strong non-genetic risk factors. Atherosclerosis is the major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24098343
DOI: 10.1371/journal.pone.0074642
PMCID: PMC3789744

Genes

ADAMTS9
TNFRSF8
WWOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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