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Article

Genetic variations in G-protein signal pathways influence progression of coronary artery calcification: Results from the Heinz Nixdorf Recall study.

Atherosclerosis - 1 Oct 2020

Klenke Stefanie, Lehmann Nils, Erbel Raimund, Jöckel Karl-Heinz, Siffert Winfried, Frey Ulrich H, Peters Jürgen

Abstract excerpt

BACKGROUND AND AIMS: Coronary artery calcification (CAC) is one of the most sensitive and specific markers of coronary atherosclerosis and believed to be heritable. We hypothesized that functionally relevant single-nucleotide polymorphisms (SNPs) in the G-protein signal pathway, which have been previously related to coronary artery disease, are associated with CAC progression. METHODS: 3108 participants from the...

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PMID: 32680596
DOI: 10.1016/j.atherosclerosis.2020.06.020

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