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Article

Genome-wide analysis of carotid plaque burden suggests a role of IL5 in men.

PloS one - 1 Jan 2020

Pott Janne, Beutner Frank, Horn Katrin, Kirsten Holger, Olischer Kay, Wirkner Kerstin, Loeffler Markus, Scholz Markus

Abstract excerpt

BACKGROUND: Carotid artery plaque is an established marker of subclinical atherosclerosis with pronounced sex-dimorphism. Here, we aimed to identify genetic variants associated with carotid plaque burden (CPB) and to examine potential sex-specific genetic effects on plaque sizes. METHODS AND RESULTS: We defined six operationalizations of CPB considering plaques in common carotid arteries, carotid bulb, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32469969
DOI: 10.1371/journal.pone.0233728
PMCID: PMC7259763

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