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Article

Pathogen DNA as target for host-generated oxidative stress: role for repair of bacterial DNA damage in Helicobacter pylori colonization.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003

O'Rourke Eyleen J, Chevalier Catherine, Pinto A Viviana, Thiberge Jean Michel, Ielpi Luis, Labigne Agnès, Radicella J Pablo

Abstract excerpt

Helicobacter pylori elicits an oxidative stress during host colonization. This oxidative stress is known to cause lesions in the host DNA. Here we addressed the question as to whether the pathogen DNA is subject to lethal or mutational damage by the host-generated oxidative response. H. pylori Hpnth mutants unable to repair oxidized pyrimidines from the bacterial DNA were generated. H. pylori strains lacking a...

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Identifiers

PMID: 12601164
DOI: 10.1073/pnas.0337641100
PMCID: PMC151419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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