Inflammation, DNA Damage, Helicobacter pylori and Gastric Tumorigenesis

Abstract excerpt

Helicobacter pylori (H. pylori) is a Gram negative bacterium that colonizes the stomach of almost half human population. It has evolved to escape immune surveillance, establishes lifelong inflammation, predisposing to genomic instability and DNA damage, notably Double Strand Breaks (DSBs). The epithelial host cell responds by activation of DNA Damage Repair (DDR) machinery that seems to be compromised by the...

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