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Article

Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection.

Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2010

Sheh Alexander, Lee Chung Wei, Masumura Kenichi, Rickman Barry H, Nohmi Takehiko, Wogan Gerald N, Fox James G, Schauer David B

Abstract excerpt

Helicobacter pylori is a human carcinogen, but the mechanisms evoked in carcinogenesis during this chronic inflammatory disease remain incompletely characterized. We determined whether chronic H. pylori infection induced mutations in the gastric mucosa of male and female gpt delta C57BL/6 mice infected for 6 or 12 mo. Point mutations were increased in females infected for 12 mo. The mutation frequency in this...

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Identifiers

PMID: 20699385
DOI: 10.1073/pnas.1009017107
PMCID: PMC2930535

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MPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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