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Article

Analysis of transforming growth factor beta 1 (TGF-beta1) gene polymorphisms in Turkish patients with scleroderma.

Cell biochemistry and function - 1 Jun 2010

Büyük U, Ates O, Dalyan L, Müsellim B, Ongen G, Topal-Sarikaya A

Abstract excerpt

Systemic sclerosis (SSc) is an autoimmune disease characterized by inflammation and fibrosis of the skin and visceral organs. Fibrosis associated with SSc is characterized by an increased synthesis of a wide range of extracellular matrix (ECM). TGF-beta is a pluripotent cytokine in a wide range of cell types. In particular it has been found to be a potent inducer of ECM protein synthesis and fibroblast migration....

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PMID: 20517890
DOI: 10.1002/cbf.1649

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