Association of TIMP-1 +372 SNP with digital ulcer manifestation in female systemic sclerosis patients.

doi:10.1016/j.humimm.2012.07.040

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Article

Association of TIMP-1 +372 SNP with digital ulcer manifestation in female systemic sclerosis patients.

Human immunology - 1 Sept 2012

Skarmoutsou Evangelia, D'Amico Fabio, Marchini Maurizio, Malaponte Grazia, Scorza Raffaella, Mazzarino Maria Clorinda

Abstract excerpt

A candidate gene for TIMP-1 gene located on the X-chromosome (rs4898) was selected for a control case study to investigate a possible association of this SNP with the susceptibility to systemic sclerosis and its digit ulcer manifestation. A total of 461 individuals of Italian Caucasian origin (228 SSc patients and 233 healthy control subjects) were genotyped for TIMP-1 +372 T/C single nucleotide polymorphism...

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PMID: 22820628
DOI: 10.1016/j.humimm.2012.07.040

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