Article
Genome-wide search for sarcoidosis susceptibility genes in African Americans.
Genes and immunity - 1 Sept 2005
Iannuzzi M C, Iyengar S K, Gray-McGuire C, Elston R C, Baughman R P, Donohue J F, Hirst K, Judson M A, Kavuru M S, Maliarik M J, Moller D R, Newman L S, Rabin D L, Rose C S, Rossman M D, Teirstein A S, Rybicki B A
Abstract excerpt
Sarcoidosis, a systemic granulomatous disease of unknown etiology, likely results from an environmental insult in a genetically susceptible host. In the US, African Americans are more commonly affected with sarcoidosis and suffer greater morbidity than Caucasians. We searched for sarcoidosis susceptibility loci by conducting a genome-wide, sib pair multipoint linkage analysis in 229 African-American families...
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