Article
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.
Cell - 8 Sept 2006
Inoki Ken, Ouyang Hongjiao, Zhu Tianqing, Lindvall Charlotta, Wang Yian, Zhang Xiaojie, Yang Qian, Bennett Christina, Harada Yuko, Stankunas Kryn, Wang Cun-Yu, He Xi, MacDougald Ormond A, You Ming, Williams Bart O, Guan Kun-Liang
Abstract excerpt
Mutation in the TSC2 tumor suppressor causes tuberous sclerosis complex, a disease characterized by hamartoma formation in multiple tissues. TSC2 inhibits cell growth by acting as a GTPase-activating protein toward Rheb, thereby inhibiting mTOR, a central controller of cell growth. Here, we show that Wnt activates mTOR via inhibiting GSK3 without involving beta-catenin-dependent transcription. GSK3 inhibits the...
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