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Article

A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Nie Duyu, Sahin Mustafa

Abstract excerpt

Tuberous sclerosis complex (TSC) is an autosomal dominant disease caused by mutations in either of two genes, TSC1 or TSC2, whose protein products form a complex that is essential in the regulation of mammalian target of rapamycin (mTOR) activity. TSC is characterized by the presence of benign tumors called hamartomas, which within the brain are known as cortical tubers. Neurological manifestations in TSC...

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Source

Identifiers

PMID: 22125080
DOI: 10.1007/978-1-61779-430-8_25

Genes

TSC2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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