Article
Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain.
Development (Cambridge, England) - 1 Dec 1996
Brand M, Heisenberg C P, Jiang Y J, Beuchle D, Lun K, Furutani-Seiki M, Granato M, Haffter P, Hammerschmidt M, Kane D A, Kelsh R N, Mullins M C, Odenthal J, van Eeden F J, Nüsslein-Volhard C
Abstract excerpt
Mutations in two genes affect the formation of the boundary between midbrain and hindbrain (MHB): no isthmus (noi) and acerebellar (ace). noi mutant embryos lack the MHB constriction, the cerebellum and optic tectum, as well as the pronephric duct. Analysis of noi mutant embryos with neuron-specific antibodies shows that the MHB region and the dorsal and ventral midbrain are absent or abnormal, but that the...
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