Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2018

Suryavanshi Santosh V, Jadhav Shweta M, Anderson Kody L, Katsonis Panagiotis, Lichtarge Olivier, McConnell Bradley K

Abstract excerpt

One of the crucial cardiac signaling pathways is cAMP-mediated PKA signal transduction, which is regulated by a family of scaffolding proteins, i.e., A-kinase anchoring proteins (AKAPs). Muscle-specific AKAP (mAKAP) partly regulates cardiac cAMP/PKA signaling by binding to PKA and phosphodiesterase 4D3 (PDE4D3), among other proteins, and plays a central role in modulating cardiac remodeling. Moreover, genetics...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A Kinase Anchor Proteins
Share to Binding Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Cyclic AMP

Share to Cyclic AMP-Dependent Protein Kinases

Share to Cyclic Nucleotide Phosphodiesterases, Type 4

Share to HEK293 Cells

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 29600899
DOI: 10.1152/ajpheart.00034.2018
PMCID: PMC6087776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling.PMID 29600899Read ↗

Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular SystemSemantic proximity Read ↗

Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP).Semantic proximity Read ↗

Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.Semantic proximity Read ↗

Mutation of an A-kinase-anchoring protein causes long-QT syndrome.Semantic proximity Read ↗

The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer.Semantic proximity Read ↗

Disease association of cyclase-associated protein (CAP): Lessons from gene-targeted mice and human genetic studiesSemantic proximity Read ↗

Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.Semantic proximity Read ↗

Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation.Semantic proximity Read ↗

AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans.Semantic proximity Read ↗

Overlapping Phenotype of Adult-Onset ALPK3 -Cardiomyopathy in the Setting of Two Novel VariantsSemantic proximity Read ↗

Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis.Semantic proximity Read ↗

Single-nucleotide polymorphisms in vascular Ca2+-activated K+-channel genes and cardiovascular disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.