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Article

Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10.

Journal of perinatology : official journal of the California Perinatal Association - 1 Mar 2012

Łoniewska B, Clark J S, Kaczmarczyk M, Adler G, Biñczak-Kuleta A, Kordek A, Horodnicka-Józwa A, Dawid G, Rudnicki J, Ciechanowicz A

Abstract excerpt

OBJECTIVE: Cyclic adenosine monophosphate/protein kinase A (PKA) is important in embryonic development. The human AKAP10 gene is polymorphic: 1936A>G results in changes to a PKA-binding domain and increased targeting to mitochondria. Previous studies found G1936 as 'deleterious' in adults, and this study investigates whether this holds true in preterm birth. STUDY DESIGN: Study group consisted of 80 preterm...

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Source

Identifiers

PMID: 21701445
DOI: 10.1038/jp.2011.85

Genes

AKAP10

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Related research

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Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10.PMID 21701445Read ↗

Polymorphism 1936A > G in the AKAP10 gene (encoding A-kinase-anchoring protein 10) is associated with higher cholesterol cord blood concentration in Polish full-term newsborns.Semantic proximity Read ↗

1936A→G (I646 V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10 in very long-lived poles is similar to that in newborns.Semantic proximity Read ↗

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Association of 1936A > G in AKAP10 (A-kinase anchoring protein 10) and blood pressure in Polish full-term newborns.Semantic proximity Read ↗

The functional genetic variant Ile646Val located in the kinase binding domain of the A-kinase anchoring protein 10 is associated with familial breast cancer.Semantic proximity Read ↗

A-kinase anchoring proteins 10 expression in relation to 2073A/G polymorphism and tumor progression in patients with colorectal cancer.Semantic proximity Read ↗

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