Article
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2003
Kammerer Stefan, Burns-Hamuro Lora L, Ma Yuliang, Hamon Sara C, Canaves Jaume M, Shi Michael M, Nelson Matthew R, Sing Charles F, Cantor Charles R, Taylor Susan S, Braun Andreas
Abstract excerpt
The focus of human genetics in recent years has shifted toward identifying genes that are involved in the development of common diseases such as cancer, diabetes, cardiovascular diseases, and Alzheimer's disease. Because many complex diseases are late-onset, the frequencies of disease susceptibility alleles are expected to decrease in the healthy elderly individuals of the population at large because of their...
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