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Article

Direct repeats in mitochondrial DNA and mammalian lifespan.

Mechanisms of ageing and development - 1 Oct 2006

Khaidakov Magomed, Siegel Eric R, Shmookler Reis Robert J

Abstract excerpt

Mitochondria have long been suspected to be among the leading determinants of aging due to their functional importance and accelerated deterioration caused by accumulation of mutations in the mitochondrial DNA. Direct repeats are known to contribute to deletion formation in mtDNA and are a powerful source of reactive oxygen species (ROS)-independent mutagenesis. To evaluate the potential importance of...

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PMID: 16956646
DOI: 10.1016/j.mad.2006.07.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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