Article

Mitochondrial Deletions and Healthspan: Lessons from the Common Repeat

2024-09-03

Abstract excerpt

Aging, characterized by a series of functional declines correlated with advancing chronological age, has a significant mitochondrial DNA (mtDNA) component, with somatic mtDNA deletions playing a central role. In post-mitotic or slow-dividing cells like neurons and skeletal muscles, selfish mtDNA deletions clonally expand within a cell, ultimately leading to the deterioration and death of host cells and appearence...

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Literature Corpus work: 36dee1d5-3399-5cc2-a9ce-4b74c719406a
DOI: 10.1101/2024.09.02.610808

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