Article
Analysis of repeat-mediated deletions in the mitochondrial genome of Saccharomyces cerevisiae.
Genetics - 1 Dec 2005
Phadnis Naina, Sia Rey A, Sia Elaine A
Abstract excerpt
Mitochondrial DNA deletions and point mutations accumulate in an age-dependent manner in mammals. The mitochondrial genome in aging humans often displays a 4977-bp deletion flanked by short direct repeats. Additionally, direct repeats flank two-thirds of the reported mitochondrial DNA deletions. The mechanism by which these deletions arise is unknown, but direct-repeat-mediated deletions involving polymerase...
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