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Article

[Clozapine-induced agranulocytosis: genetic risk factors and an immunologic explanatory model].

Tijdschrift voor psychiatrie - 1 Jan 2006

Güzelcan Y, Scholte W F

Abstract excerpt

BACKGROUND: Clozapine, an atypical antipsychotic used in the treatment of refractory schizophrenia, causes agranulocytosis in 0.8% of patients. The risk factors for clozapine-induced agranulocytosis (CIA) and the underlying mechanisms are unclear. AIM: To ascertain the genetic and immunological r...

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Source

Identifiers

PMID: 16955993

Genes

NQO2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16955993-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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[Clozapine-induced agranulocytosis: genetic risk factors and an immunologic explanatory model].PMID 16955993Read ↗

Clozapine-induced agranulocytosis and its genetic determinants.Semantic proximity Read ↗

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Drug-induced agranulocytosis: impact of different fcgamma receptor polymorphisms?Semantic proximity Read ↗

Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis.Semantic proximity Read ↗

Clozapine-induced agranulocytosis in schizophrenic Caucasians: confirming clues for associations with human leukocyte class I and II antigens.Semantic proximity Read ↗

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Further evidence of human leukocyte antigen-encoded susceptibility to clozapine-induced agranulocytosis independent of ancestry.Semantic proximity Read ↗

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.Semantic proximity Read ↗

Genetic determinants of drug-induced agranulocytosis: potential risk of olanzapine?Semantic proximity Read ↗

Clozapine Pharmacogenetic Studies in Schizophrenia: Efficacy and AgranulocytosisSemantic proximity Read ↗

NQO2 gene is associated with clozapine-induced agranulocytosis.Semantic proximity Read ↗

Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis.Semantic proximity Read ↗

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