Article
Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population.
Biological psychiatry - 15 Oct 2016
Saito Takeo, Ikeda Masashi, Mushiroda Taisei, Ozeki Takeshi, Kondo Kenji, Shimasaki Ayu, Kawase Kohei, Hashimoto Shuji, Yamamori Hidenaga, Yasuda Yuka, Fujimoto Michiko, Ohi Kazutaka, Takeda Masatoshi, Kamatani Yoichiro, Numata Shusuke, Ohmori Tetsuro, Ueno Shu-Ichi, Makinodan Manabu, Nishihata Yosuke, Kubota Masaharu, Kimura Takemi, Kanahara Nobuhisa, Hashimoto Naoki, Fujita Kiyoshi, Nemoto Kiyotaka, Fukao Taku, Suwa Taro, Noda Tetsuro, Yada Yuji, Takaki Manabu, Kida Naoya, Otsuru Taku, Murakami Masaru, Takahashi Atsushi, Kubo Michiaki, Hashimoto Ryota, Iwata Nakao
Abstract excerpt
BACKGROUND: Clozapine-induced agranulocytosis (CIA)/clozapine-induced granulocytopenia (CIG) (CIAG) is a life-threatening event for schizophrenic subjects treated with clozapine. METHODS: To examine the genetic factor for CIAG, a genome-wide pharmacogenomic analysis was conducted using 50 subjects with CIAG and 2905 control subjects. RESULTS: We identified a significant association in the human leukocyte antigen...
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