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Article

Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis

1 Aug 2009

Abstract excerpt

Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years support a significant role for this family of transcription factors in carcinogenesis. KLFs can both activate and repress genes that participate in cell-cycle regulation. Among...

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PMID: 20119532
DOI: 10.2174/138920209788921010

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