Article
Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr.
Science (New York, N.Y.) - 2 Nov 2001
de Noronha C M, Sherman M P, Lin H W, Cavrois M V, Moir R D, Goldman R D, Greene W C
Abstract excerpt
Human immunodeficiency virus-1 (HIV-1) Vpr expression halts the proliferation of human cells at or near the G2 cell-cycle checkpoint. The transition from G2 to mitosis is normally controlled by changes in the state of phosphorylation and subcellular compartmentalization of key cell-cycle regulatory proteins. In studies of the intracellular trafficking of these regulators, we unexpectedly found that wild-type Vpr,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.