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Human immunodeficiency virus type 1 Vpr: functions and molecular interactions

10 Jul 2009

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is an accessory protein that interacts with a number of cellular and viral proteins. The functions of many of these interactions in the pathogenesis of HIV-1 have been identified. Deletion of the vpr gene reduces the virulence of HIV-1 dramatically, indicating the importance of this protein for the virus. This review describes the current findings...

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PMID: 19458171
DOI: 10.1099/vir.0.011726-0

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