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Article

The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A.

The Biochemical journal - 1 Jul 2008

Zhang Yong, Liu Suya, Lajoie Gilles, Merrill A Rod

Abstract excerpt

eEF2 (eukaryotic elongation factor 2) contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of diphtheria toxin, cholix toxin and Pseudomonas aeruginosa exotoxin A. Site-directed mutagenesis was conducted on residues within the diphthamide-containing loop (Leu693-Gly703) of eEF2 by replacement with alanine. The purified yeast eEF2 mutant...

Read the complete abstract on PubMed

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Share to Adenosine Diphosphate Ribose
Share to ADP Ribose Transferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bacterial Toxins

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Share to Gene Expression Regulation, Fungal

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Share to Mutagenesis, Site-Directed

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Source

Identifiers

PMID: 18373493
DOI: 10.1042/BJ20071083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A.PMID 18373493Read ↗

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