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Article

Dominant-negative mutant phenotypes and the regulation of translation elongation factor 2 levels in yeast.

Nucleic acids research - 1 Jan 2005

Ortiz Pedro A, Kinzy Terri Goss

Abstract excerpt

The eukaryotic translation elongation factor 2 (eEF2), a member of the G-protein superfamily, catalyzes the post-peptidyl transferase translocation of deacylated tRNA and peptidyl tRNA to the ribosomal E- and P-sites. eEF2 is modified by a unique post-translational modification: the conversion of His699 to diphthamide at the tip of domain IV, the region proposed to mimic the anticodon of tRNA. Structural models...

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Share to Peptide Chain Elongation, Translational

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16214807
DOI: 10.1093/nar/gki882
PMCID: PMC1253829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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