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Article

PIIMS Server: A Web Server for Mutation Hotspot Scanning at the Protein-Protein Interface.

Journal of chemical information and modeling - 25 Jan 2021

Wu Feng-Xu, Yang Jing-Fang, Mei Long-Can, Wang Fan, Hao Ge-Fei, Yang Guang-Fu

Abstract excerpt

Protein-protein interactions (PPIs) play vital roles in regulating biological processes, such as cellular and signaling pathways. Hotspots are certain residues located at protein-protein interfaces that contribute more in protein-protein binding than other residues. Research on the mutational effects of hotspots is important for understanding basic aspects of protein association. Hence, various computational...

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PMID: 33400510
DOI: 10.1021/acs.jcim.0c00966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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