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Article

Chemical double-mutant cycles: dissecting non-covalent interactions.

Chemical Society reviews - 1 Feb 2007

Cockroft Scott L, Hunter Christopher A

Abstract excerpt

Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems.

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Identifiers

PMID: 17264921
DOI: 10.1039/b603842p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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