Chemical double-mutant cycles: dissecting non-covalent interactions.

doi:10.1039/b603842p

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Chemical double-mutant cycles: dissecting non-covalent interactions.

Chemical Society reviews - 1 Feb 2007

Cockroft Scott L, Hunter Christopher A

Abstract excerpt

Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems.

Topics

Amino Acids
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Models, Molecular
Mutation
Protein Conformation
Proteins
Static Electricity
Thermodynamics

Source

Open in PubMed

Identifiers

PMID: 17264921
DOI: 10.1039/b603842p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics