Article
Fusogenic domain and lysines in saposin C.
Archives of biochemistry and biophysics - 15 Apr 2004
Qi Xiaoyang, Chu Zhengtao
Abstract excerpt
Saposin C, a sphingolipid activator protein with fusogenic activity, interacts specifically with the membrane containing negatively charged, unsaturated phospholipids. The kinetics and mechanism of saposin C-induced membrane fusion were previously investigated using acidic phospholipid liposomes. A hypothetic clip-on model for such a fusion process was illustrated by the ionic binding between saposin C and...
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