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Article

Complimentary action of structured and unstructured domains of epsin supports clathrin-mediated endocytosis at high tension.

Communications biology - 8 Dec 2020

Joseph Jophin G, Osorio Carlos, Yee Vivian, Agrawal Ashutosh, Liu Allen P

Abstract excerpt

Membrane tension plays an inhibitory role in clathrin-mediated endocytosis (CME) by impeding the transition of flat plasma membrane to hemispherical clathrin-coated structures (CCSs). Membrane tension also impedes the transition of hemispherical domes to omega-shaped CCSs. However, CME is not completely halted in cells under high tension conditions. Here we find that epsin, a membrane bending protein which...

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Identifiers

PMID: 33293652
DOI: 10.1038/s42003-020-01471-6
PMCID: PMC7722716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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