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Article

Alterations in the properties of the cell membrane due to glycosphingolipid accumulation in a model of Gaucher disease.

Scientific reports - 9 Jan 2018

Batta Gyula, Soltész Lilla, Kovács Tamás, Bozó Tamás, Mészár Zoltán, Kellermayer Miklós, Szöllősi János, Nagy Peter

Abstract excerpt

Gaucher disease is a lysosomal storage disease characterized by the malfunction of glucocerebrosidase resulting in the accumulation of glucosylceramide and other sphingolipids in certain cells. Although the disease symptoms are usually attributed to the storage of undigested substrate in lysosomes, here we show that glycosphingolipids accumulating in the plasma membrane cause profound changes in the properties of...

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Identifiers

PMID: 29317695
DOI: 10.1038/s41598-017-18405-8
PMCID: PMC5760709

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STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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